Risk Keys
Drug induced lupus
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Induced by a variety of drugs, most commonly procainamide, hydralazine, isoniazid and penicillamine
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Usually mild, although vasculitis may occur
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Symptoms resolve within seven months after withdrawal of causative drug
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Anti-histone is the distinctive test. ANA is positive, and all other autoantibodies are absent.
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| Interpretation of antinuclear antibody (ANA) and other autoantibody tests |
| ANA result typically includes a description of the pattern of fluorescence, such as "nucleolar" or "speckled." Although each pattern correlates roughly with specific connective tissue diseases, the linkage is too weak to use in diagnosis. The table shows the most likely diagnosis for each autoantibody test. Many of these tests are positive in most connective tissue diseases. Proper diagnosis or underwriting classification requires correlation of test results with the clinical picture. |
| ANA negative |
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| Ro |
SLE |
| Jo |
Polymyositis |
| cardiolipin |
Antiphospholipid syndrome |
| ANA positive |
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| RNA polymerase I |
CREST |
| centromere |
Mixed connective tissue disease |
| U1-snRNP |
Mixed connective tissue disease |
| dsDNA |
SLE |
| ssDNA |
SLE |
| Sm |
SLE |
| Histone |
Drug-induced lupus |
| Ro (SS-A) |
Sjögren's syndrome |
| La (SS-B) |
Sjögren's syndrome |
| Scl-70 |
Progressive systemic sclerosis |
| Jo |
Polymyositis |
| Ku |
Polymyositis |
| Mi-2 |
Polymyositis/dermatomyositis |
| Rheumatoid factor |
Rheumatoid arthritis |
| CCP |
Rheumatoid arthritis |
